Archive for January, 2023

A Plea to PCPs: Please Do a DRE on Male Patients (or Refer to Urology to do so)

January 28, 2023

Andrew Siegel MD   1/28/2023

A DRE (digital rectal exam) is a VITAL component of the male physical exam in which a gloved, lubricated finger is placed gently within the rectum to examine the accessible surface of the prostate and gain valuable information about its health. Although not a pleasant examination, it is brief and not painful. Urologists do not relish performing a DRE any more than a patient desires receiving one, but it provides essential information that cannot be derived by any other means. If the prostate has an abnormal consistency, a hardness, lump, bump, or simply feels uneven and asymmetrical, it may be a sign of prostate cancer, the most common cancer in men and one that causes no symptoms in its earliest stages. The region of the prostate that is accessible via DRE — the peripheral zone — is the site of origin of most cases of prostate cancer.

“The only circumstances in which a male patient does not get a DRE are if he has no rectum, the physician has no finger, or the patient is having an acute cardiac event.”

Dr. Ganesh Pallauttu, (Chairman of Urology, University of Michigan), paraphrased from a recent lecture

The slender examining digit of yours truly, estimated to have performed more than 100,000 prostate exams

DRE in conjunction with the PSA (prostate specific antigen) blood test are the best tools to screen for prostate cancer.  The two tests are complementary — each providing unique information — and it is entirely possible to have a prostate cancer with a normal PSA, the cancer presenting only with an abnormal DRE.  Detection rates for prostate cancer are highest when using both tests, followed by PSA alone, followed by DRE alone. The pathological features of prostate cancers detected on an abnormal DRE are generally less favorable than those of cancers detected by a PSA elevation. In other words, if the cancer is palpable, there is more concern than if it cannot be felt, as it is often at a more advanced stage.

Some of my patients have told me that their PCP informed them that a PSA test can replace the DRE.  That is blatant misinformation. Disinformation. Fake news. Under no circumstance does PSA replace the DRE, unless the DRE is a physical impossibility because of the patient not having a rectum.

Some aggressive and poorly differentiated prostate tumors are notorious for being so undifferentiated that they do not elaborate much PSA, particularly neuroendocrine tumors that are primarily diagnosed by an abnormality on DRE.

These are high tech times, and we have all sorts of fancy and sophisticated imaging tests to evaluate the prostate, e.g., multiparametric MRI, but the good old DRE remains a vital part of the physical exam of a male patient and should never be marginalized or forsaken.  In addition to providing valuable information on prostate size, symmetry, and palpable irregularities, it also offers insights concerning anal/rectal tone, the presence of rectal masses, the tonicity of the pelvic floor muscles, and permits testing for occult blood.  The price of DRE is right while the price of not doing one can be costly if a delayed diagnosis of prostate cancer is the outcome.  Many patients expect a DRE as part of a physical exam, and many will question the thoroughness of an exam that does not include one. 

Within the last month, I picked up a rectal cancer on DRE done for purposes of examining the prostate.  The prostate felt fine, but the rectum overlying the prostate was rough and irregular and the diagnosis of rectal cancer was confirmed upon referral to the colorectal surgeon. 

DRE is clearly dirty business for the physician wielding the digit, certainly much less refined than examining a patient with a stethoscope.  It is also momentarily uncomfortable for the patient.  Nonetheless, it is necessary business.  If a physician is apprehensive doing a DRE or they question their digital diagnostic skill and acumen, simply referring the patient to a urology colleague is in order.  It is our pleasure.

During office hours earlier this week I received a referral from a medical doctor with the above message stamped onto a prescription. I was very pleased!
Image from PROSTATE CANCER 20/20: A Practical Guide to Understanding Treatment Options for Patients and Their Families ( I am working diligently on a second edition)

Case Study: 50-something-year-old male referred for evaluation of urinary frequency. His DRE revealed asymmetry, with the right side of the prostate firmer than the left.  PSA was normal at 2.2. Prostate biopsy demonstrated the following:

The biopsy showed an aggressive Gleason 7 (4+3) cancer that was managed with a robotic-assisted laparoscopic prostatectomy. The urinary frequency had absolutely nothing to do with the prostate cancer as most early prostate cancers cause no symptoms, hence the need for screening DRE and PSA.  Had this man not had the DRE and only had the PSA, this cancer would have been missed and the potential for curative intervention lost.  

Bottom Line:  Prostate cancer is the most common malignancy in men (aside from skin cancer) and in its earliest phases is most often asymptomatic, thus the need for screening DRE and PSA. Prostate cancers may be diagnosed because of an abnormal DRE even in the face of a normal or low PSA. Low PSA-secreting yet high-grade aggressive prostate cancers can be missed if a DRE is forsaken. The DRE is a vital and imperative part of the male physical exam that provides valuable information and should not be omitted. 

Wishing you the best of health,

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Dr. Andrew Siegel is a physician and urological surgeon who is board-certified in urology as well as in female pelvic medicine and reconstructive surgery.  He is an Assistant Clinical Professor of Surgery at the Rutgers-New Jersey Medical School and is a Castle Connolly Top Doctor New York Metro AreaInside Jersey Top Doctor and Inside Jersey Top Doctor for Women’s Health. His mission is to “bridge the gap” between the public and the medical community. He is a urologist at New Jersey Urology, one of the largest urology practices in the United States.  He is the co-founder of PelvicRx and Private Gym.  His latest book is Prostate Cancer 20/20: A Practical Guide to Understanding Management Options for Patients and Their Families. 

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Video trailer for Prostate Cancer 20/20

Preview of Prostate Cancer 20/20

Andrew Siegel MD Amazon author page

PROSTATE CANCER 20/20 is now available at Audible, iTunes and Amazon as an audiobook read by the author (just over 6 hours). 

Dr. Siegel’s other books:

THE KEGEL FIX: Recharging Female Pelvic, Sexual, and Urinary Health


MALE PELVIC FITNESS: Optimizing Sexual and Urinary Health

PROMISCUOUS EATING— Understanding and Ending Our Self-Destructive Relationship with Food